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Omni 1000

Delivering deep biological insight with absolute quantification across 1,000 judiciously selected proteins — balancing comprehensive pathway coverage, clinical relevance, and discovery-ready utility.

Broad Coverage, Real-World Utility

92% Most Valuable Proteins

Percentage of most valuable proteins (MVPs) captured on Omni, curated from top literature, mid-plex panels, endpoint assays, and pharma-preferred pathways to maximize relevance for discovery and development.

100% Level 0 Reactome Coverage

Reflects the percentage of top-level biological systems captured on Omni, ensuring full representation across foundational cellular and physiological processes as defined by Reactome’s highest organizational tier.

84% Level 1 Reactome Coverage

Represents the proportion of detailed functional pathways covered within each top-level system. This metric captures the depth of Omni’s biological breadth, mapping into specific molecular cascades and processes across human biology.

100% MeSH Disease Classes

Tracks Omni’s ability to cover protein markers across all MeSH disease categories, ensuring broad utility for disease biology by aligning with the standard NIH classification of human health conditions.

100% KEGG Drug Discovery Pathways

Measures Omni’s coverage of the 46 most studied KEGG pathways, prioritized based on pharmaceutical pipeline activity, enabling high relevance to drug discovery and translational research across therapeutic areas.

95% Disease Prediction Power

Benchmarked against UK Biobank data, this metric reflects how much of the disease-predictive signal from a large 3,000-protein panel is retained by Omni’s overlapping 800-protein subset.

92%

of Most Valuable Proteins

100%

Level 0 Reactome Coverage

80%

Level 1 reactome coverage

100%

MSH Disease Classes

100%

KEGG Drug Discovery Pathways

95%

Disease Prediction Power

How we selected the most informative 1000 proteins

The Omni 1000 panel was designed through a two-pronged strategy. We first curated the Most Valuable Proteins — well-established biomarkers with proven utility across drug discovery and translational research. Second, we used a data-driven approach — applying machine learning and optimization methods on public high-plex proteomic datasets. The result was 1000 proteins that maximize biological coverage and recapitulate patient phenotypic information, all while minimizing redundancy.

Nomic Omni 1000 Target Library

Explore the list of Omni protein targets.

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Results 1

Filtering by:
Tag
Operator
Value
Target Name
Uniprot ID
Gene Name
filter-tests
‍
APOE
P02649
APOE
5.4 Digestive system
6.7 Neurodegenerative disease
Omni 1000
Flex
Gene expression (Transcription)
Metabolism
Metabolism of proteins
Sensory Perception
Signal Transduction
Transport of small molecules
Vesicle-mediated transport
Secreted
Cytoplasm
APOC3
P02656
APOC3
5.2 Endocrine system
5.4 Digestive system
Omni 1000
Flex
Metabolism
Sensory Perception
Transport of small molecules
Secreted
APOC1
P02654
APOC1
5.4 Digestive system
Omni 1000
Flex
Signal Transduction
Transport of small molecules
Secreted
APOA4
P06727
APOA4
5.4 Digestive system
6.9 Cardiovascular disease
Omni 1000
Flex
Metabolism
Metabolism of proteins
Sensory Perception
Transport of small molecules
Secreted
APOA2
P02652
APOA2
5.2 Endocrine system
5.4 Digestive system
Omni 1000
Flex
Metabolism
Metabolism of proteins
Sensory Perception
Transport of small molecules
Secreted
APOA1
P02647
APOA1
5.2 Endocrine system
5.4 Digestive system
6.5 Infectious disease: parasitic
6.9 Cardiovascular disease
Omni 1000
Core CardioMet
Flex
Cellular responses to stimuli
Disease
Hemostasis
Metabolism
Metabolism of proteins
Sensory Perception
Transport of small molecules
Vesicle-mediated transport
Secreted
APLP1
P51693
APLP1
No items found.
Omni 1000
Flex
No items found.
Cell Membrane
Cytoplasm
APEX1
P27695
APEX1
2.4 Replication and repair
Omni 1000
Core CardioMet
Flex
DNA Repair
Nucleus
Cytoplasm
APCS
P02743
APCS
No items found.
Omni 1000
Flex
Metabolism of proteins
Secreted
ANXA4
P09525
ANXA4
No items found.
Omni 1000
Flex
No items found.
Cytoplasm
ANTXR2
P58335
ANTXR2
5.1 Immune system
Omni 1000
Flex
No items found.
Secreted
Cell Membrane
Cytoplasm
ANTXR1
Q9H6X2
ANTXR1
5.1 Immune system
Omni 1000
Flex
No items found.
Cell Membrane
ANGPTL7
O43827
ANGPTL7
No items found.
Omni 1000
Core CardioMet
Flex
No items found.
Secreted
ANGPTL4
Q9BY76
ANGPTL4
5.2 Endocrine system
5.4 Digestive system
Omni 1000
Core CardioMet
Flex
Cell-Cell communication
Developmental Biology
Metabolism
Transport of small molecules
Secreted
ANGPTL3
Q9Y5C1
ANGPTL3
5.4 Digestive system
Omni 1000
Core CardioMet
Flex
Signal Transduction
Transport of small molecules
Secreted
ANGPTL2
Q9UKU9
ANGPTL2
No items found.
Omni 1000
Core CardioMet
Flex
No items found.
Secreted
ANGPT4
Q9Y264
ANGPT4
3.2 Signal transduction
Omni 1000
Core CardioMet
Flex
Hemostasis
Secreted
ANGPT2
O15123
ANGPT2
3.2 Signal transduction
6.3 Infectious disease: viral
Omni 1000
Flex
Hemostasis
Secreted
ANGPT1
Q15389
ANGPT1
3.2 Signal transduction
6.6 Immune disease
Omni 1000
Core Immune
Core CardioMet
Flex
Hemostasis
Signal Transduction
Secreted
ALPP
P05187
ALPP
1.0 Global and overview maps
1.8 Metabolism of cofactors and vitamins
Omni 1000
Flex
Vesicle-mediated transport
Cell Membrane
ALK
Q9UM73
ALK
6.1 Cancer: overview
6.2 Cancer: specific types
Omni 1000
Flex
Disease
Signal Transduction
Cell Membrane
ALCAM
Q13740
ALCAM
3.3 Signaling molecules and interaction
Omni 1000
Core CardioMet
Flex
Developmental Biology
Secreted
Cell Membrane
ALB
P02768
ALB
5.2 Endocrine system
Omni 1000
Core CardioMet
Flex
Cellular responses to stimuli
Drug ADME
Hemostasis
Metabolism
Metabolism of proteins
Transport of small molecules
Vesicle-mediated transport
Secreted
AKT3
Q9Y243
AKT3
3.2 Signal transduction
4.1 Transport and catabolism
4.2 Cell growth and death
4.3 Cellular community - eukaryotes
4.5 Cell motility
5.1 Immune system
5.2 Endocrine system
5.3 Circulatory system
5.4 Digestive system
5.6 Nervous system
5.8 Development and regeneration
5.9 Aging
6.1 Cancer: overview
6.2 Cancer: specific types
6.3 Infectious disease: viral
6.4 Infectious disease: bacterial
6.5 Infectious disease: parasitic
6.7 Neurodegenerative disease
6.9 Cardiovascular disease
6.10 Endocrine and metabolic disease
6.12 Drug resistance: antineoplastic
Omni 1000
Flex
Cell Cycle
Cellular responses to stimuli
Developmental Biology
Disease
Gene expression (Transcription)
Immune System
Programmed Cell Death
Signal Transduction
Vesicle-mediated transport
Nucleus
Cytoplasm
AKT1
P31749
AKT1
3.2 Signal transduction
4.1 Transport and catabolism
4.2 Cell growth and death
4.3 Cellular community - eukaryotes
4.5 Cell motility
5.1 Immune system
5.2 Endocrine system
5.3 Circulatory system
5.4 Digestive system
5.6 Nervous system
5.8 Development and regeneration
5.9 Aging
6.1 Cancer: overview
6.2 Cancer: specific types
6.3 Infectious disease: viral
6.4 Infectious disease: bacterial
6.5 Infectious disease: parasitic
6.7 Neurodegenerative disease
6.9 Cardiovascular disease
6.10 Endocrine and metabolic disease
6.12 Drug resistance: antineoplastic
Omni 1000
Core Immune
Core CardioMet
Flex
Cell Cycle
Cellular responses to stimuli
Developmental Biology
Disease
Gene expression (Transcription)
Hemostasis
Immune System
Metabolism
Metabolism of RNA
Programmed Cell Death
Signal Transduction
Vesicle-mediated transport
Cell Membrane
Nucleus
Cytoplasm
AKR1B10
O60218
AKR1B10
1.0 Global and overview maps
1.1 Carbohydrate metabolism
1.3 Lipid metabolism
1.8 Metabolism of cofactors and vitamins
Omni 1000
Flex
Metabolism
Sensory Perception
Secreted
Cytoplasm
AHSG
P02765
AHSG
No items found.
Omni 1000
Core CardioMet
Flex
Hemostasis
Immune System
Metabolism of proteins
Secreted
AGT
P01019
AGT
No items found.
Omni 1000
Flex
Metabolism
Metabolism of proteins
Signal Transduction
Secreted
AGRP
O00253
AGRP
5.2 Endocrine system
Omni 1000
Core CardioMet
Flex
Gene expression (Transcription)
Secreted
Cytoplasm
AGRN
O00468
AGRN
3.3 Signaling molecules and interaction
4.5 Cell motility
Omni 1000
Flex
Developmental Biology
Disease
Extracellular matrix organization
Metabolism
Sensory Perception
Secreted
Cell Membrane
AGR2
O95994
AGR2
No items found.
Omni 1000
Flex
No items found.
Secreted
Cytoplasm
AGER
Q15109
AGER
4.1 Transport and catabolism
5.1 Immune system
6.7 Neurodegenerative disease
6.9 Cardiovascular disease
6.10 Endocrine and metabolic disease
Omni 1000
Core Immune
Core CardioMet
Flex
Immune System
Secreted
Cell Membrane
Nucleus
Cytoplasm
AFP
P02771
AFP
3.2 Signal transduction
Omni 1000
Flex
Metabolism of proteins
Secreted
AFM
P43652
AFM
No items found.
Omni 1000
Flex
No items found.
Secreted
ADIPOQ
Q15848
ADIPOQ
3.2 Signal transduction
5.2 Endocrine system
5.9 Aging
6.10 Endocrine and metabolic disease
Omni 1000
Core CardioMet
Flex
Developmental Biology
Metabolism
Secreted
ADGRG1
Q9Y653
ADGRG1
No items found.
Omni 1000
Flex
No items found.
Secreted
Cell Membrane
ADGRE5
P48960
ADGRE5
No items found.
Omni 1000
Flex
Immune System
Signal Transduction
Secreted
Cell Membrane
ADGRB3
O60242
ADGRB3
No items found.
Omni 1000
Flex
No items found.
Cell Membrane
ADAMTS5
Q9UNA0
ADAMTS5
No items found.
Omni 1000
Flex
Disease
Extracellular matrix organization
Metabolism of proteins
Secreted
ADAMTS2
O95450
ADAMTS2
No items found.
Omni 1000
Flex
Disease
Extracellular matrix organization
Metabolism of proteins
Secreted
ADAMTS13
Q76LX8
ADAMTS13
5.1 Immune system
Omni 1000
Core CardioMet
Flex
Disease
Hemostasis
Metabolism of proteins
Secreted
ADAMTS1
Q9UHI8
ADAMTS1
No items found.
Omni 1000
Flex
Disease
Extracellular matrix organization
Metabolism of proteins
Secreted
ADAM9
Q13443
ADAM9
4.1 Transport and catabolism
Omni 1000
Flex
Extracellular matrix organization
Secreted
Cell Membrane
ADAM8
P78325
ADAM8
No items found.
Omni 1000
Flex
Extracellular matrix organization
Immune System
Cell Membrane
ADAM28
Q9UKQ2
ADAM28
No items found.
Omni 1000
Flex
No items found.
Secreted
Cell Membrane
ADAM23
O75077
ADAM23
No items found.
Omni 1000
Flex
Developmental Biology
Secreted
Cell Membrane
ADAM22
Q9P0K1
ADAM22
No items found.
Omni 1000
Core CardioMet
Flex
Developmental Biology
Cell Membrane
ADAM17
P78536
ADAM17
3.2 Signal transduction
4.1 Transport and catabolism
6.3 Infectious disease: viral
6.4 Infectious disease: bacterial
6.7 Neurodegenerative disease
Omni 1000
Flex
Disease
Extracellular matrix organization
Immune System
Signal Transduction
Cell Membrane
ADAM12
O43184
ADAM12
No items found.
Omni 1000
Flex
Extracellular matrix organization
Signal Transduction
Secreted
Cell Membrane
ADAM10
O14672
ADAM10
4.1 Transport and catabolism
6.4 Infectious disease: bacterial
6.7 Neurodegenerative disease
Omni 1000
Flex
Developmental Biology
Disease
Extracellular matrix organization
Immune System
Metabolism of proteins
Signal Transduction
Cell Membrane
Cytoplasm
ACVRL1
P37023
ACVRL1
3.3 Signaling molecules and interaction
Omni 1000
Flex
Signal Transduction
Cell Membrane
ACVR2B
Q13705
ACVR2B
3.2 Signal transduction
3.3 Signaling molecules and interaction
4.3 Cellular community - eukaryotes
6.9 Cardiovascular disease
Omni 1000
Flex
Developmental Biology
Signal Transduction
Cell Membrane
ACTA2
P62736
ACTA2
3.2 Signal transduction
4.5 Cell motility
5.2 Endocrine system
5.3 Circulatory system
Omni 1000
Flex
Muscle contraction
Signal Transduction
Cytoplasm
ACP5
P13686
ACP5
1.0 Global and overview maps
1.8 Metabolism of cofactors and vitamins
4.1 Transport and catabolism
5.8 Development and regeneration
6.6 Immune disease
Omni 1000
Core CardioMet
Flex
Metabolism
Cytoplasm
ACP3
P15309
ACP3
No items found.
Omni 1000
Flex
Immune System
Secreted
Cell Membrane
Nucleus
Cytoplasm
ACP1
P24666
ACP1
1.0 Global and overview maps
1.8 Metabolism of cofactors and vitamins
4.3 Cellular community - eukaryotes
6.1 Cancer: overview
Omni 1000
Flex
No items found.
Cytoplasm
ACHE
P22303
ACHE
1.3 Lipid metabolism
5.6 Nervous system
Omni 1000
Flex
Metabolism
Metabolism of proteins
Neuronal System
Secreted
Cell Membrane
Nucleus
ACE2
Q9BYF1
ACE2
5.2 Endocrine system
5.4 Digestive system
6.3 Infectious disease: viral
Omni 1000
Core CardioMet
Flex
Disease
Metabolism of proteins
Secreted
Cell Membrane
Cytoplasm
ACE
P12821
ACE
5.2 Endocrine system
6.3 Infectious disease: viral
6.5 Infectious disease: parasitic
6.9 Cardiovascular disease
Omni 1000
Core CardioMet
Flex
Metabolism of proteins
Secreted
Cell Membrane
Cytoplasm
ACAT1
P24752
ACAT1
1.0 Global and overview maps
1.1 Carbohydrate metabolism
1.3 Lipid metabolism
1.5 Amino acid metabolism
1.9 Metabolism of terpenoids and polyketides
5.4 Digestive system
Omni 1000
Flex
Metabolism
Metabolism of proteins
Cytoplasm
ACAN
P16112
ACAN
No items found.
Omni 1000
Flex
Disease
Extracellular matrix organization
Metabolism
Secreted
ABO
P16442
ABO
1.0 Global and overview maps
1.7 Glycan biosynthesis and metabolism
Omni 1000
Flex
Metabolism
Secreted
Cytoplasm
A2M
P01023
A2M
5.1 Immune system
Omni 1000
Flex
Extracellular matrix organization
Hemostasis
Transport of small molecules
Secreted
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Omni 1000: Biological Intelligence Delivered at Scale

Resources

News
•
October 6, 2026

Nomic’s Proteomics Platform to Power VO Health’s Molecular Fitness Insights

VO Health’s Molecular Fitness Blood Test™ will utilize deep protein profiling to estimate VO₂ Max and characterize the biological pathways underlying cardiorespiratory fitness and performance
Dataset
•

Perturb PBMC

Functional Proteomics of the PBMC Secretome
Application Note
•
August 16, 2026

Proteomics for Drug Safety Assessment

Detect toxicity before candidates advance. This application note shows how high-throughput proteomic profiling can reveal toxicity signals while helping resolve the mechanisms behind them.
On Demand
•
July 16, 2026

Interpreting CRISPR Screens Through Protein-Level Biology

Amanda McQuade and Nathaniel Robichaud discuss how integrated proteomic and transcriptomic profiling can reveal cellular responses to genetic perturbations that are not captured through RNA analysis alone.
News
•
June 25, 2026

Nomic joins the HESI Global OASIS Consortium to Advance Human-Relevant Safety Assessment Through Proteomics

Study will profile over 3,000 human liver-derived samples to generate proteomic training datasets for New Approach Methodologies and AI-enabled toxicity prediction
News
•
June 16, 2026

Nomic and Wellcome Sanger Institute Collaborate to Bring Protein-Level Resolution to the Genetics of Immune Diversity

High-plex protein profiling across 1,500+ perturbed PBMC samples enables functional mapping of immune genetics across diverse Latin American cohorts
News
•
April 20, 2026

Nomic and Broad Clinical Labs Partner to Integrate Omni 1000 into Discovery and Translational Workflows

Nomic and Broad Clinical Labs partner to unlock broader applications for proteomics through high-plex, quantitative data that enables cross-study comparable insights.
Application Note
•
April 19, 2026

Proteomics: Stop inferring biology, start measuring it

Discover how scalable, quantitative proteomics bridges drug development from discovery screens to clinical translation
White Paper
Nomic Bio
•
April 18, 2026

Omni 1000: Biological Intelligence Delivered at Scale

Proteomics has long required compromise: breadth versus cost, absolute quantification versus depth, scalability versus insight. Omni 1000 eliminates those constraints, delivering 1063 rigorously selected proteins in a single quantitative assay, yielding data that is interoperable across studies.
On Demand
•
March 19, 2026

Video: Perturb PBMC - Functional Proteomics of the PBMC Secretome

Hosted by Nathaniel Robichaud, PhD, Partnerships Lead at Nomic, this video explores findings from our large-scale PBMC screen and their implications for multiple sclerosis.
News
•
November 11, 2025

Perturb-PBMC: Functional Proteomics of the PBMC Secretome

News
•
November 7, 2025

Nomic Publishes Foundational Protein Quantification Technology in Nature Methods

The company highlights how its technology powers large-scale proteomic perturbation studies, unveiling Perturb-PBMC, a 1.4 million–protein PBMC dataset available in the Nomic Portal.
On Demand
•
October 17, 2025

Watch: Currents of Pan-Cancer - Insights from 1,000 Circulating Proteins

In this webinar Lloyd Bod, PhD and Nathaniel Robichaud, PhD, will discuss how large-scale profiling of the circulating proteome across multiple cancer types reveals unique tumor-specific protein signatures and provides new insights into treatment response.
News
•
September 4, 2025

Nomic Bio Awards Omni 1000 Proteomics Grants to Seven Institutions, Enabling 5 Million Data Points Across 5,000 Samples

Technical note
•
July 22, 2025

Nomic Platform Validation Methods and Results

Nomic’s nELISA® technology is a versatile, proteome-wide multiplexed solution designed for scalable, high-throughput protein quantification. At its core is a library of 1,000 expertly curated assays developed to support drug development and biomarker discovery.
Brochure
Nomic Bio
•
May 30, 2025

Protein Profiling Brochure

Proteomics without Compromise
News
•
May 13, 2025

Omni 1000 Grant Opportunity in High Plex Proteomics

News
•
May 13, 2025

Nomic Bio Debuts $50 Proteome with Absolute Quantification Through Launch of Omni 1000

For the first time, researchers can access a quantitative proteome-wide solution that profiles 1000 of the most informative proteins at high-throughput.
On Demand
•
May 13, 2025

Watch: 1000 Proteins to Unlock the Proteome

1000 Proteins to Unlock the Proteome: Delivering Affordable, Scalable, and Quantitative Proteomics.
Technical note
Nomic Bio
•
November 1, 2024

The nELISA: A Massively Multiplexed & Miniaturized Immunoassay Platform for High-Throughput Protein Profiling

How nELISA miniaturizes immunoassays on beads, overcoming reagent-driven cross-reactivity and reducing costs.
Publication
Milad Dagher & David Juncker
•
April 18, 2023

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the secretome

BioRxiv ; We present the nELISA, a miniaturised, high-throughput, and high-fidelity protein profiling platform.
White Paper
Nomic Bio
•
October 16, 2024

True Multiplexing with the nELISA

True Multiplexing Unlocks Scalable Proteomics
Technical note
Nomic Bio
•
January 14, 2025

Using the nELISA™ to Map Cytokine Interactions in a 10,000-well PBMC Perturbation Screen

High-throughput protein profiling technology enables comprehensive and quantitative mapping of cytokine interactions
News
Nomic Bio
•
September 24, 2024

Nomic® and Parker Institute for Cancer Immunotherapy (PICI) Launch Large-Scale Protein Profiling to Investigate Immunotherapy Responses in RADIOHEAD Study

Project will quantify circulating protein markers in ~3000 patient blood samples from PICI’s RADIOHEAD study using Nomic’s nELISA™ high-throughput protein profiling platform to better understand how patients respond to treatment
News
Nomic Bio
•
December 8, 2021

Nomic Closes $17 Million Series A to Develop and Commercialize the World’s Highest Throughput Proteomic Platform

Nomic is closing of an oversubscribed US$17 million Series A funding round, bringing the company's total funding to date to over US$21 million.
News
Nomic Bio
•
June 28, 2023

Nomic Bio Appoints Byron Hewett to its Board of Directors

Hewett brings invaluable operational and strategic expertise to guide Nomic Bio through its crucial years of growth.
News
Nomic Bio
•
December 8, 2021

Nomic to Provide nELISA to JUMP Cell Painting Consortium to Measure Protein Secretome for Phenotypic Drug Discovery

Nomic’s nELISA will be used to profile 200 secreted proteins for ten thousand samples to provide consortium partners complementary information about the secretome
Brochure
Nomic Bio
•
January 13, 2025

How To Access the nELISA Service

Accessing our profiling service is a simple and seamless experience. We offer comprehensive, end-to-end support to help you harness the power of the proteome.
News
Nomic Bio
•
September 17, 2024

Nomic® Secures $42M in Oversubscribed Series B to Expand Access to Protein Profiling

The fresh capital will enable Nomic to accelerate the expansion of its commercial operations, further invest in advancing its state-of-the-art protein profiling platform, and broaden its transformative offerings to meet growing demand.
News
MIlad Dagher, CEO
•
January 3, 2025

Bridging the Gaps in Proteomics

Enabling well-powered studies, absolute quantification, and unlimited content flexibility